The common rejection module in chronic rejection post lung transplantation

Rejection after Lung Transplantation?

How does the body recognize the donor lung as different? Your body’s natural immune cells are able to recognize small, unique proteins called “antigens” that are present on the surface of all cells or infectious particles. These immune cells, called the T cells and the B cells, can recognize the antigens as “self” if they belong to you or “non-self” if they do not belong to you (such as those i...

Lung rejection after transplantation.

With the introduction of Cyclosporine as an immunosuppressive agent, combined heart and lung transplantation (HLTx) became an effective treatment for severe pulmonary vascular disease [1] and has been extended successfully to treat end-stage lung disease [2] and cystic fibrosis [3, 4]. Single lung transplantation offers a treatment for cryptogenic fibrosing alveolitis [5]. It was initially beli...

Chronic rejection in renal transplantation

Hyperacute rejection following lung transplantation.

Although hyperacute rejection has been clinically and pathologically fully described in recipients of other solid organ transplants, to our knowledge, there have been no previous fully documented cases in recipients of lung transplants. This case of clinical hyperacute rejection is corroborated by a positive, donor-antigen-specific IgG-mediated lymphocytotoxic crossmatch (LXM), and demonstrated...

Mechanisms of chronic rejection in cardiothoracic transplantation.

Despite significant improvements in early post-transplantation survival rates, long-term patient and graft survival have remained poor, due in large part to the vexing problem of chronic allograft rejection. Attempts to combat this problem with intensification of immunosuppression have led to concomitant increases in the rates of fatal malignancies and infections. In cardiac transplantation, ch...